- Audrey Irby - Meliza Irizarry-Byrd
- Marsha Industrious - Mario Irigoyen
- Iris Innis - Lauren Ibgui
- Alicia Indelicato - Savannah Irvin
- Francisco Iglesias - Roberta Infante
- Ailyn Irio - Maria Izquierdo
- Priscilla Iglesias - Raheem Ivey
- SAMANTHA IRINEOU - Yelena Iskander
- Kristen Inzerillo - Bryan Irvin
- Alma Ibarra - Debra Ingersoll
- Tamara Iversen - CONSUELO INOVERO
- DARLENE IRIZARRY - MAGDA ITURRINO
- CAROL IVEY - James Irving
- Eddie Irizarry - Syeda Idrisi
- Elliot Irizarry Bonilla - ALEXANDER IZZO
- NICHOLAS INZETTI - Ruth Irby
- BRENDA IZOLD - BRETT IACOVONE
- EDWIN INGALLS - Joanne Isgro