- Shanen Osterman - Kerry Oliver-Smith
- SUSAN OLIPHANT - Lori Overstreet
- Lewis Orsich - Ivan Ocasio
- Lewis Orenstein - Etem Oksayoglu
- Casandra Osio Martin - Elizabeth Oquendo
- Loreal O'Neill - Michael Ore
- David Ozoria - Martha Ocampo
- Mirtha Odell - Reinaldo Ocasio Velez
- James Oneil - Arlene Obrien
- JALEN OLIVER - Eric Otto
- Diana Ortiz - CASEY OWENS
- Carlos Oliva - Salvadora Otero
- Gabriella Ocner - Marale Orihuela
- Blanca Ortiz - Nichole Ortiz
- Maria Ortega - Oscar Oconor
- Arian Orta - Kary Olivera
- Corina Ortiz - Alfredo Olmos Padilla
- Luis Otero - Beatrice Ortega
- KIRK OSWELL - Angela Osteen
- Sean O'Donnell - Richard Oliver
- EDWARD OWENS - MELANIE OSBORNE
- Robin Outlaw - REBECCA ORTIZ
- Sergio Osorio - Gialisa Ocasio Cedres
- Alejandro Olalde - Bernard Owens
- Camille Ortiz Rodriguez - Kristian Ortiz
- Senija Orlovic - Brent Olsson
- Grace Oconnor - Lena Odom
- Joel Ortiz Olivero - Priscilla Ortiz
- Victoria Orlando - Julia Oneill
- Wendy Ogando - Charles Overbey JR
- MONROE OLIFF - Kenneth Owens
- Nicholas O Connor - JOHN OVERBY JR
- MARITZA ORTIZ - LISA ORR
- Darlene Olich - Patricia Ortlip
- CARIL OWEN - ALFREDO OSORIO
- JUAN ORTIZ TORRES - NELLY ONTIVEROS CERVANTES
- ALBERTA OBRIAN - ALEXANDRIA ONLY
- BRANDON OUTLAW - SILVIA OLMO COTTO
- JALNA ONEIL - Mark Ortiz
- Jose Orozco - Craig Outler
- Billy Omer - Nicole Ortiz Henriquez
- Samuel Okun - Regina O'Bryan
- MICHAEL ONEIL - SILVANIA O'DONNELL
- Samuel Owen - Kristopher Olin
- Michele Opton - Victor Ortiz Graulau
- JIMMY OQUENDO - MARIO OLIVA
- NORMAN OROPEZA SR - LAURA OLDANIE
- DOUGLAS O'DONNELL - CARLOS ORTIZ GONZALEZ
- Eric Overstreet - Raymond Otto JR
- Angela Orlowski - Mildred Oliver
- Taylor O'Connor - ROBERT ORTHWEIN II
- KAREN O'SHEA - CATHERINE ORN
- JESSICA ORTA - CARMEN OQUENDO
- Melissa O'Donnell - Brandon Otwell
- IVETTE ORELLANA - ROGER OLSON
- HANNAH O'STEEN - Anthony Oddo
- Karen Ostrowski - Karla Ojeda Best